Materials Science Major
IWATA Eri Professor
Animal behavior, nerve physiology, veterinary science
Animals' behavioral patterns are said to be significantly affected by environmental factors. In our laboratory, we are conducting studies on environmental factors, especially focusing on the relationship between social structure and the behavioral expression pattern of individual organisms using fish as our model animals, thus aiming to elucidate the behavioral expression mechanisms of animals.
UMEMURA Kazuyuki Professor／Doctor of Science
Synthesis of natural and physiologically-active substances, Organic synthetic chemistry
- Synthesis and research of thiostrepton antibiotics Thiostrepton antibiotics are a group of cyclic peptide antibiotics that show reactivity to Gram-positive bacteria and have pyridine-thiazole structure as their basic framework.
- Development and research of new reactions using organic sulfur/selenium compounds We are engaged in development and research of new reactions by taking advantage of characteristics of sulfur and selenium atoms represented by reactions of S-adenosylmethionine inside an organism.
- Research on synthesis of other physiologically active substances
KAWAGUCHI Kiichiro Professor／Doctor of Pharmaceutical Science
Pharmacognosy, pharmaceutical food science
We proved that a citrus flavonoid can inhibit the production of the tumor necrosis factor (TNF-α) induced by lipopolysaccharide (LPS), endotoxin shock, and Salmonella typhimurium-induced shock. We also proved that the citrus flavonoid can alleviate the pathogenesis of collagen-induced arthritis (CIA), which is an experimental model for arthrorheumatism. Furthermore, clinical trials in patients with arthrorheumatism proved the availability of hesperidin glycoside. Later we found that grape berry skin, grape seed powder, and olive berry powder could strongly inhibit LPS induction, TNF-α production, and CIA pathogenesis. We are currently isolating active ingredients from oil-expressed olive berry and from grape berry skin and grape seeds, which are industrial waste products produced during wine preparation, and are conducting the structural analysis of the ingredients in order to find an effective method to refine active ingredients rapidly and in large quantity as well as to study their immunopharmacology effect.
KIKUCHI Yuji Professor／Ph.D in Medicine
We are analyzing how living organisms activate their immunological and allergic reactions to bacteria and viruses on the molecular, cellular, and individual animal levels. We aim to apply these findings to the development of therapeutic agents or preventive medicines (vaccines) for infectious diseases and allergies.
NAKATA Yoshiyuki Professor／Doctor of Engineering
Physical metallurgy/diffraction crystallography
(1) To investigate into the relevance between metal/alloy microstructure and their physical properties, in particular, the impact of defect structure and regularity turbulence onto phase transition (phase transformation) by using electron microscopes. (2) To determine and analyze X-ray absorption microstructure and electron energy loss microstructure, and elucidate change in local structure and electronic state of specific elements accompanying amorphous crystallization process and phase transition. (3) To predict physical properties and structure of unknown samples and substances that are difficult to determine, by means of band calculation. e.g. prediction of atom displacement accompanying magnetic moment of artificial lattice and displacement-type phase transition.
HAYASHI Masahiko Professor
Pharmacology in medical pharmacy
We are searching for new substances with novel anti-cancer effects, anti-inflammatory effects, and antiallergic properties. Using these substances, we analyze their action mechanisms, evaluate their effects through experiments using animals in pathological conditions, and develop lead compounds for drugs and medicines.
YAMAURA Masanori Professor／Doctor of Science
Molecular design chemistry
Research is centered around 2 major themes: development of new reactions and synthesis of useful organic compounds. In terms of reaction, new reactions utilizing properties of rare earth elements are actively developed. In addition, we are working on correlation of structural reactivity of natural product synthesis and physiologically active natural products by utilizing such reactions.